Clotting Phenomena at the Blood-Polymer Interface and Development of Blood Compatible Polymeric Surfaces

In the past two decades many attempts have been made to relate surface and interfacial parameters with the blood compatibility of polymeric surfaces. It is however doubtful if by a single parameter the behaviour of blood on a surface can be predicted. Two major aspects of blood compatibility—the prevention of platelet adhesion and the deactivation of the intrinsic coagulation system are determined by the measure and nature of competitive blood protein adsorption on the foreign surface. The adhesion of blood platelets is promoted by adsorbed fibrinogen and gamma globulin, while adsorbed albumin inhibits platelet adhesion. Heparinised surfaces do not adsorb fibrin and consequently no adhesion of platelets takes place. Other surfaces with low platelet adhesion are the hydrogels, certain block copolyetherurethanes, polyelectrolyte complexes and biolised proteins. Heparinised surfaces of the cationically bonded type inhibit the intrinsic coagulation as well, however this may be due to unstable coatings and heparin leakage. In the authors laboratory a synthetic heparinoid was prepared with the structure - [CH₂ - C(CH₃ NHSO₃ Na - C(H) COONa - CH₂ -] x? with M?_w = (7.5 /pm 1.0) × 10⁵ and an in vivo anticoagulant activity of 50% of heparin. Its coatings on PVC, using tridodecylmethyl-ammonium chloride as a coupling agent, are stable in plasma and salt solutions and provide surfaces which show negligible platelet adhesion and a strong inhibition of the intrinsic coagulation on contact with blood. Similar results were found with polydimethylsiloxane surfaces coated with this heparinoid.     

EPDM rubber reinforced with titania generated by nonhydrolytic sol‐gel process

EPDM rubber was reinforced with titania in situ generated by using a nonhydrolytic sol‐gel (NHSG) process starting from TiCl₄ as titania precursor and tert‐butanol as oxygen donor. Titania particles in anatase form and with average diameter of 6 nm were synthesized via NHSG route and then the same procedure was adopted in presence of EPDM rubber to obtain composites containing up to 30 wt% of filler. Extraction and equilibrium swelling tests suggested an interfering effect of the NHSG reaction on the vulcanization process of the rubber resulting to a crosslink density which decreased in the presence of titania. Quasi‐static and dynamic‐mechanical characterizations indicated that the presence of titania as rigid filler in both the unvulcanized and vulcanized EPDM matrix led to a significant increase in stiffness and stress at break. The experimental values of modulus were systematically higher than the values predicted by classical equations suggesting an additional stiffening contribution deriving from the molecular interaction between the rubber and the filler. POLYM. ENG. SCI., 54:2544–2552, 2014. © 2013 Society of Plastics Engineers     

Influence of in situ‐generated silica nanoparticles on EPDM morphology,thermal, thermomechanical,and mechanical properties

Silica nanoparticles were synthesized by means of a sol–gel method and generated in ethylene propylene diene monomer rubber (EPDM) by in situ synthesis. The properties were determined using scanning electron microscopy, attenuated total reflectance Fourier‐transform infrared spectroscopy, thermogravimetric analysis, tensile testing, dynamic mechanical analysis, swelling tests, and gel content determination. The silica particles were homogenously dispersed in the EPDM matrix, with the presence of agglomerates, especially for high silica contents. The swelling experiments showed a decrease in the crosslinking density of the vulcanized rubber due to the presence of the silica nanoparticles. The mechanical properties, however, were significantly improved by the presence of the stiff silica nanoparticles. The effect of the amount of silica on the thermomechanical properties and thermal degradation of EPDM was also investigated. The presence of silica showed an increase in the storage and loss moduli at high temperatures, probably due to the increasing filler content. The thermal degradation analysis showed that the presence of silica particles incorporated in the EPDM matrix had no significant influence on the thermal stability of the composites. POLYM. COMPOS., 36:825–833, 2015. © 2014 Society of Plastics Engineers     

The Role of Target Binding Kinetics in Drug Discovery

Traditionally structure–activity/affinity relationships (SAR) have dominated research in medicinal chemistry. However, structure–kinetics relationships (SKR) can be very informative too. In this viewpoint we explore the molecular determinants of binding kinetics and discuss challenges for future binding kinetics studies. A scheme for future kinetics‐directed drug design and discovery is also proposed.     

Reshaping markets for the benefit of energy saving

Energy saving is an important option for preventing emission of greenhouse gases. Furthermore, when energy saving is reducing the spatial and temporal density of energy consumption, it supports a rising market share of renewable energy sources. Last but not the least, energy saving plays a role in reducing the vulnerability for import dependency and supply disruptions. Despite these virtues energy saving and energy efficiency, being typically demand side options, appear to be harder to ‘sell’ than the other options which focus on the supply side. The currently prevailing market-based approach in energy policy initially brought setbacks for energy saving. The introductory article and the selected contributions to this special issue intend to show that markets can and should be shaped to the benefit of the uptake and of the potential of energy saving. To this end, all elements of the energy efficiency delivery context should be addressed in energy-saving policies. Learning, measurement and observation are important tools in this reshaping process. All contributions are based on papers of the European Council for an Energy Efficient Economy 2003 Summer Study.